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DPPIV drug discovery kit Biomol/BML-AK499

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產品名稱: DPPIV drug discovery kit Biomol/BML-AK499
產品型號: 原裝進口,現(xiàn)貨
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簡單介紹

DPPIV drug discovery kitEnzo lifescience BML-AK499；二肽基肽酶 4 /二肽基肽酶IV 檢測試劑盒；原裝進口，現(xiàn)貨供應！


DPPIV drug discovery kit Biomol/BML-AK499  的詳細介紹

DPPIV drug discovery kit    Enzo lifescience BML-AK499；二肽基肽酶 4 /二肽基肽酶IV  檢測試劑盒，原裝進口，現(xiàn)貨供應！

The DPPIV Drug Discovery Kit is a complete assay system designed to screen DPPIV inhibitors, providing enough material to perform at least 96 assays. DPPIV (DPP4, CD26) is a member of the class of proteases known as prolyl peptidases, which cleave proteins after proline residues and is thought to play roles in diabetes, cancer, and autoimmune diseases, making it a target for drug discovery.

The kit contains both a chromogenic substrate (H-Gly-Pro-pNA; Km=114 µM) and a fluorogenic substrate (H-Gly-Pro-AMC; Km=50 µM).

Cleavage of the p-nitroaniline (pNA) from the colorimetric substrate increases absorbance at 405 nm. The fluorimetric assay is based on the cleavage of 7-amino-4-methylcoumarin (AMC) moiety from the C-terminus of the peptide substrate, which increases its fluorescence intensity at 460 nm. The kit is useful to screen inhibitors of DPPIV, a potential therapeutic target. A DPPIV inhibitor, P32/98 (KI=130 nM12), is included for use as a control. Other DPP enzymes are available for specificity profiling.

Product Specification

Alternative Name:CD26 drug discovery kit, Dipeptidyl Peptidase IV drug discovery kit, DPP4 drug discovery kit
 
Long Term Storage:-80°C
 
Kit/Set Contains:DPPIV Enzyme (Human, recombinant) (Prod. No. BML-SE434-9090) (35 mU (40.4µl); 0.867 mU/µl. On U=1µmole/min@37°C, 100µM H-Gly-Pro-pNA. Purity ≥95% (SDS-Page)) Storage: -70°C; avoid freeze thaw cycles
pNA substrate (Prod. No. BML-PI188-9090) (150µl; 10mM in DMSO) Storage: -70°C
Calibration standard (p-nitroaniline) (Prod. No. BML-KI106) (1ml; 50µM in assay buffer) Storage: -70°C
AMC Substrate (Prod. No. BML-P189-9090) (150µl; 0.5mM in DMSO) Storage: -70°C

 

Calibration standard (7-Amino-4-methylcoumarin) (Prod. No. BML-KI107) (1ml; 40µM in assay buffer) Storage: -70°C)
Inhibitor (Prod. No. BML-PI142-9090) (20µl; 1mM in DMSO) Storage: -70°C
Assay Buffer (50mM TRIS, pH 7.5) (Prod. No. BML-KI342) (20ml; liquid in screw-cap plastic bottle) Storage: -20 or -70°C
½-volume clear microplate (Prod. No. BML-K101)Storage: Room temperature


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